Related Experiment Video
Updated: Jul 28, 2026

11:34
High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Synthesis and biological evaluation of 2-methoxy- and 2-methylthio-6-[2'-alkylamino)ethyl]-4(3H)-pyrimidinones with
M Botta1, F Occhionero, R Nicoletti
1Dipartimento Farmaco Chimico Tecnologico, Banchi di Sotto 55, Universitá degli Studi, Siena, Italy. botta@unisi.it
Bioorganic & Medicinal Chemistry
|October 26, 1999
Abstract:
The synthesis of a new family of antiviral compounds, 2-methoxy-, and 2-methylthio-6-[(2'-alkylamino)ethyl]-4(3H)-pyrimidinones, has been accomplished. The activity of these agents against positive strand (rubella virus and sindbis virus) and negative strand (vesicular stomatitis virus) RNA viruses is reported. Some of these compounds are efficient and selective inhibitors of rubella virus.

