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Cancer biology: extracellular proteinases in malignancy
1Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232, USA. Lynn.Matrisian@mcmail.Vanderbilt.edu
Current Biology : CB
|October 26, 1999
Abstract:
Secreted, matrix-degrading proteinases have been viewed as contributing to tumor metastasis. A recent study indicates that the gene for one of these enzymes, the matrix metalloproteinase stromelysin-1, can actually cause cancer when expressed in transgenic mice.