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Urease-based mucosal immunization against Helicobacter heilmannii infection induces corpus atrophy in mice
C Dieterich1, H Bouzourène, A L Blum
1Division of Gastroenterology, Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland.
Infection and Immunity
|October 26, 1999
Abstract:
Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage.