Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Yeast Signaling01:28

Yeast Signaling

17.3K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
17.3K
Location and Orientation of the Heart01:13

Location and Orientation of the Heart

10.5K
The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
10.5K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

5.8K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
5.8K
Methods of Documentation I: Source-Oriented Records01:18

Methods of Documentation I: Source-Oriented Records

1.7K
Source-oriented records, or SOR, are medical record-keeping organized by the data source. The SOR system was first developed in the mid-1900s to organize the growing patient data in hospitals and other healthcare facilities.
In an SOR, each discipline involved in patient care maintains a separate medical record section. This record-keeping method enables easy tracking of patient progress and ensures healthcare staff have access to up-to-date information.
Key Attributes include the following:
1.7K
Genetic Screens02:46

Genetic Screens

5.7K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.7K
Overview of Microsoft Excel as a Data Analysis Tool01:13

Overview of Microsoft Excel as a Data Analysis Tool

1.6K
Microsoft Excel is a cornerstone tool for data analysis and statistical operations, offering a wide array of functionalities to manage, analyze, and visualize data efficiently. Recognized for its versatility, Excel facilitates the performance of basic to complex statistical operations, serving as an indispensable asset for analysts, researchers, and students alike. Excel's significance in data analysis emanates from its spreadsheet environment, where data can be organized in rows and...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is psychotherapy effective? A re-analysis of treatments for depression.

Epidemiology and psychiatric sciences·2018
Same author

Stimulation of adult hippocampal neurogenesis by physical exercise and enriched environment is disturbed in a CADASIL mouse model.

Scientific reports·2017
Same author

A rejoinder from Gerger and colleagues.

Psychological medicine·2014
Same author

Integrating fragmented evidence by network meta-analysis: relative effectiveness of psychological interventions for adults with post-traumatic stress disorder.

Psychological medicine·2014
Same author

Which are the best tools for specific clinical application (chips, multiplex, mass spec profile, etc.)?

Clinical chemistry and laboratory medicine·2003
Same author

The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva.

Virology·2001
Same journal

Perfusion development and its potential for cell therapy manufacturing with adherent cells.

Applied microbiology and biotechnology·2026
Same journal

Bacterial degradation of aromatic ester pollutants in agro-ecosystems: implications for bioremediation.

Applied microbiology and biotechnology·2026
Same journal

Inhibiting biofilm growth on ammonium salt-functionalized or fluorinated voice prostheses silicone.

Applied microbiology and biotechnology·2026
Same journal

Enhancing reproducibility in mixing time determination of stirred tank reactors via automated analysis and standardized inter-laboratory trials.

Applied microbiology and biotechnology·2026
Same journal

Hybrid genome assembly and phenotypic assays reveal carbohydrate metabolism diversity in Lacticaseibacillus strains.

Applied microbiology and biotechnology·2026
Same journal

Ammonium and nitrate fluxes drive metabolic functional shifts in tap water biofilms.

Applied microbiology and biotechnology·2026
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

1.5K

Yeast cells as tools for target-oriented screening.

T Munder1, A Hinnen

  • 1Hans-Knöll-Institut für Naturstoff-Forschung e V. Jena, Germany.

Applied Microbiology and Biotechnology
|October 26, 1999
PubMed
Summary
This summary is machine-generated.

Understanding biomolecular interaction networks is key to cellular function and disease. New drug discovery approaches leverage these networks and conserved pathways in model organisms for robust cellular assay systems.

More Related Videos

Author Spotlight: Exploring Cytoskeletal Dynamics to Unveil Novel Antibiotics Through Innovative Cell-Based Assays
05:57

Author Spotlight: Exploring Cytoskeletal Dynamics to Unveil Novel Antibiotics Through Innovative Cell-Based Assays

Published on: April 26, 2024

1.3K
Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
07:40

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens

Published on: October 25, 2019

6.5K

Related Experiment Videos

Last Updated: Feb 8, 2026

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

1.5K
Author Spotlight: Exploring Cytoskeletal Dynamics to Unveil Novel Antibiotics Through Innovative Cell-Based Assays
05:57

Author Spotlight: Exploring Cytoskeletal Dynamics to Unveil Novel Antibiotics Through Innovative Cell-Based Assays

Published on: April 26, 2024

1.3K
Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
07:40

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens

Published on: October 25, 2019

6.5K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Biomolecular interaction networks are vital for cellular functions; disruptions contribute to disease pathogenesis.
  • Protein and nucleic acid interactions present significant drug targets, increasingly accessible via genomic research.
  • Conserved cellular structures and pathways across species facilitate the use of model organisms in research.

Purpose of the Study:

  • To highlight the importance of biomolecular interaction networks in understanding cellular processes and disease.
  • To discuss the role of these networks as targets for drug discovery.
  • To explore the utility of model organisms in developing novel screening systems.

Main Methods:

  • Review of current literature on biomolecular interactions and drug discovery.
  • Analysis of genomic research outputs for identifying potential drug targets.
  • Discussion of target-oriented bioassay systems and their development using model organisms.

Main Results:

  • Alterations in biomolecular interactions, often due to genetic aberrations, lead to disease.
  • Interactions between macromolecules offer a rich source of drug targets for pharmaceutical research.
  • Model organisms enable the creation of robust cellular assay systems for screening.

Conclusions:

  • Biomolecular interaction networks are critical for both understanding health and disease.
  • Genomic advancements provide new opportunities for drug discovery targeting these networks.
  • Model organisms are valuable tools for developing innovative and effective drug screening platforms.