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Dietary supplement-drug interactions.

S C Smolinske1

  • 1Children's Hospital of Michigan Regional Poison Control Center, USA.

Journal of the American Medical Women'S Association (1972)
|October 26, 1999
PubMed
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Many adults use prescription drugs with herbal supplements, risking interactions. Documented drug-herb interactions are rare, but bleeding risks exist with Ginkgo biloba and warfarin interactions are suggested.

Area of Science:

  • Pharmacology
  • Integrative Medicine
  • Herbal Medicine Interactions

Background:

  • 18% of US adults use prescription drugs with herbal or vitamin products.
  • This concurrent use poses risks for an estimated 15 million patients due to potential drug-supplement interactions.
  • Documented drug-herb interactions remain sparse despite widespread use.

Observation:

  • This review examines potential interactions between drugs and herbal medicines, focusing on phytoestrogens and antiplatelet/oral anticoagulant therapies.
  • Interactions with phytoestrogens are speculative, possibly involving estrogen-receptor binding or antiestrogenic effects.
  • Case reports suggest bleeding complications with Ginkgo biloba and potential interactions between warfarin and dong quai or Panax ginseng.

Findings:

Related Experiment Videos

  • While phytoestrogen interactions are theoretical, clinical evidence points to bleeding risks with Ginkgo biloba.
  • Case reports indicate potential interactions between warfarin and specific herbs like dong quai and Panax ginseng.
  • The review highlights a gap between widespread use and documented adverse events.

    • Implications:

    • Healthcare providers should counsel patients at high risk for adverse drug-herb interactions.
    • Further research is needed to clarify the mechanisms and clinical significance of documented and potential drug-herb interactions.
    • This information is crucial for improving patient safety in integrative medicine practices.