Another case of achalasia-microcephaly syndrome

Related Experiment Videos

F R Kreuz, S Nolte-Buchholtz, F Fackler

    Clinical Dysmorphology
    |October 26, 1999
    PubMed

    The first German patient with achalasia-microcephaly syndrome is described. The mother was exposed to the anti-malarial drug Mefloquine during the first 8 weeks of pregnancy.

    Related Concept Videos

    Esophageal Achalasia01:27

    Esophageal Achalasia

    Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...