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Related Experiment Videos

Immunomodulatory function of lactic acid bacteria.

H Yasui1, K Shida, T Matsuzaki

  • 1Yakult Central Institute for Microbiological Research, Tokyo, Japan.

Antonie Van Leeuwenhoek
|October 26, 1999
PubMed
Summary

This study shows that Bifidobacterium breve and Lactobacillus casei strain Shirota modulate distinct immune pathways. These probiotics offer protection against infections like rotavirus and influenza, and may inhibit tumors and IgE production.

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Area of Science:

  • Immunology
  • Microbiology
  • Probiotics

Background:

  • Lactic acid bacteria (LAB) are known for their health benefits.
  • Specific strains may have unique immunomodulatory effects.

Purpose of the Study:

  • To investigate the distinct immune-modulating effects of Bifidobacterium breve YIT4064 and Lactobacillus casei strain Shirota (LcS).
  • To assess the protective capabilities of these probiotics against specific infections and diseases.

Main Methods:

  • Oral administration of B. breve and LcS in mouse models.
  • Administration of B. breve to infants in an infant home.
  • Measurement of humoral and cellular immune responses (IgA, IgG, Th1 cells).
  • Assessment of protection against rotavirus and influenza virus infections.

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  • Monitoring of tumor incidence and IgE production.

    • Main Results:

    • B. breve activated humoral immunity, increasing anti-rotavirus IgA and anti-influenza virus IgG, protecting against these infections.
    • B. breve administration to infants reduced rotavirus shedding frequency.
    • LcS stimulated Th1 cells and cellular immunity, inhibiting tumor incidence and IgE production.
    • Both strains demonstrated distinct immunomodulatory effects.

    Conclusions:

    • B. breve and LcS modulate different immune systems uniquely.
    • These probiotics show potential for preventing various diseases, including infections and potentially cancer.
    • Probiotic interventions can be beneficial for both animal models and human infants.