Research-overview article: membrane lipolysis and cholinergic priority

Cholinergic drugs and antigenic and toxicological challenges induced lipolysis in twelve sheep. A lipolytic end product, the PGF2alpha metabolite, was found to be a reliable non-specific cholinergic marker. The lipolytic membrane alterations supported the concept of a general priority of the cholinergic system. A main feature is the breaking of molecular stability in dynamic hydrogen-bond interactions. Both acetylcholine and dioxygen reactivity are apparently moderated by cholinesterases. Free radicals appeared to be normal intermediates of catabolism, serving to neutralize excess protons. Antioxidants regenerate molecular oxygen, and so counteract part of excess activated oxygen. Intrinsic reactivity against its own structures characterizes the immuno-cholinergic system. Genetic priority could be assumed for cholinergic constituents and constitutions. A broad spectrum of etiologies was suggested. Lasting or repeated challenges may cause heterochiral conversions of vital proteins. The priority aspect of cholinergism also suggested methods to rank among the multitude of secondary biomolecules.