Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Porphyria and chemicals.

D C Downey1

  • 1Department of Oral Pathology, Gentle Dental, Beaverton, Oregon 97006, USA.

Medical Hypotheses
|October 26, 1999
PubMed
Summary
This summary is machine-generated.

Porphyria, a genetic disease, can be triggered by environmental chemicals, not just drugs. Standard diagnostic methods may be insufficient, necessitating consideration of chemical exposure in affected individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The porphyrin pathway: the final common pathway?

Medical hypotheses·2002
Same author

An association of fibromyalgia with primary Sjögren's syndrome: a prospective study of 72 patients.

The Journal of rheumatology·1995
Same author

Fatigue syndromes revisited: the possible role of porphyrins.

Medical hypotheses·1994
Same author

Hereditary coproporphyria.

The British journal of clinical practice·1994
Same author

Fatigue syndromes: new thoughts and reinterpretation of previous data.

Medical hypotheses·1992
Same author

Oral manifestations and their management in AIDS and HIV-positive patients.

The Journal of the Oregon Dental Association·1987
Same journal

Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

Medical hypotheses·2026
Same journal

Subclinical mastitis during lactation: a modifiable risk factor for breast cancer?

Medical hypotheses·2025
Same journal

The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.

Medical hypotheses·2025
Same journal

Neuron-Targeted Exosome Therapy: A Novel Approach for Treating Cardiogenic Dementia via RyR2 Inhibition.

Medical hypotheses·2025
Same journal

How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

Medical hypotheses·2024
Same journal

Unstable Plaque is a Treatable Cause of Cognitive Decline.

Medical hypotheses·2024
See all related articles

Area of Science:

  • Biochemistry
  • Toxicology
  • Genetics

Background:

  • Porphyria is a group of genetic diseases often presenting with neuropsychiatric symptoms.
  • Known triggers include drugs, infections, heavy metals, hormones, fasting, and chemicals.
  • Current drug-induced porphyria lists are extensive, but chemical triggers are less documented.

Purpose of the Study:

  • To highlight the importance of considering porphyria in cases of illness following chemical exposure.
  • To address the lack of comprehensive lists for chemical-induced porphyria.
  • To emphasize the inadequacy of standard diagnostic measures for some porphyria cases.

Main Methods:

  • Review of known porphyria triggers.
  • Comparison of drug labeling (Physicians Desk Reference) with chemical safety data sheets (Material Safety Data Sheet).

Related Experiment Videos

  • Case illustrations of potential chemical-induced porphyria.

    • Main Results:

    • Chemicals with similar structures to known porphyrogenic drugs lack adequate safety labeling.
    • Standard diagnostic approaches for porphyria may not identify all cases.
    • Three examples illustrate potential links between chemical exposure and porphyria: Turkish porphyria, Agent Orange exposure, and Gulf War syndrome.

    Conclusions:

    • Porphyria should be considered in patients with unexplained illnesses after chemical exposure.
    • Enzyme testing in the porphyrin pathway can aid in thorough patient evaluation.
    • Further research is needed to document chemical-induced porphyria and improve diagnostic strategies.