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Related Experiment Videos

Pharmacological and urodynamic changes in rat urinary bladder function after multiple pregnancies.

F Grandadam1, P Lluel, S Palea

  • 1Synthélabo Recherche, Internal Medicine Research, Rueil-Malmaison, France.

BJU International
|October 26, 1999
PubMed
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Multiple pregnancies alter rat bladder function, causing instability and increased voiding pressure. These changes mimic obstruction, suggesting hormonal influences on bladder control.

Area of Science:

  • Urology
  • Physiology
  • Pharmacology

Background:

  • Pregnancy and childbirth can significantly impact female lower urinary tract function.
  • Understanding these changes is crucial for managing postpartum urinary issues.

Purpose of the Study:

  • To investigate alterations in bladder function following multiple pregnancies and parturition in rats.
  • To correlate changes in voiding dynamics with in vitro detrusor muscle responses.

Main Methods:

  • Conscious female Wistar rats (virgin vs. multiparous) underwent continuous bladder pressure monitoring via implanted lines during voiding cycles.
  • In vitro, detrusor muscle contractile responses to KCl, carbachol, noradrenaline, and mATP were assessed.

Main Results:

Related Experiment Videos

  • Multiparous rats exhibited increased voiding pressure amplitude (+31%), bladder capacity (+83%), and residual volume (3x).
  • Bladder instability occurred in 60% of multiparous rats versus 10% of virgins.
  • Detrusor muscle showed enhanced contractile responses to carbachol and noradrenaline in multiparous rats, but sensitivity to mATP remained unchanged.

Conclusions:

  • Multiple pregnancies induce bladder hypertrophy, instability, and increased voiding pressure with higher residual volumes in rats.
  • These functional changes resemble those seen after chronic infravesical outlet obstruction.
  • Pregnancy and parturition likely modify urinary bladder function through mechanisms involving increased adrenergic and cholinergic sensitivity.