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[New diagnostic possibilities in dermatologic diseases]
1Börgyógyászati Klinika, Szent-Györgyi Albert Orvostudományi Egyetem, Szeged.
The author reviews the latest developments regarding the most important immunological methods for the diagnosis of dermatological diseases. The salt-split-skin, fluorescence overlay antigen mapping and immunoblot techniques are useful methods for the differentiation of autoimmune bullous skin diseases. The use of recombinant fusion products of antigenic epitopes in patients with pemphigus and bullous pemphigoid affords a possibility for the differentiation or diagnosis of the disease by means of a simple ELISA technique. In situ hybridization and the polymerase chain reaction (PCR) technique are very useful in many dermatological diseases to demonstrate infective agents or genetic abnormalities.
The author reviews the latest developments regarding the most important immunological methods for the diagnosis of dermatological diseases. The salt-split-skin, fluorescence overlay antigen mapping and immunoblot techniques are useful methods for the differentiation of autoimmune bullous skin diseases. The use of recombinant fusion products of antigenic epitopes in patients with pemphigus and bullous pemphigoid affords a possibility for the differentiation or diagnosis of the disease by means of a simple ELISA technique. In situ hybridization and the polymerase chain reaction (PCR) technique are very useful in many dermatological diseases to demonstrate infective agents or genetic abnormalities.