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Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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Liver Regeneration01:24

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Gross Anatomy of the Liver01:17

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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Related Experiment Video

Updated: Feb 10, 2026

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
12:35

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

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Liver tumours.

G Perilongo1, E A Shafford

  • 1Division of Paediatric Haematology-Oncology, University of Padova, Italy.

European Journal of Cancer (Oxford, England : 1990)
|October 26, 1999
PubMed
Summary
This summary is machine-generated.

Pediatric primary liver tumors are diverse, with malignant types like hepatoblastoma and hepatocellular carcinoma being more common. This review focuses on these malignant epithelial tumors in children.

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Area of Science:

  • Pediatric Oncology
  • Hepatobiliary Medicine
  • Tumor Pathology

Background:

  • Primary hepatic tumors in children are a heterogeneous group.
  • Malignant tumors constitute 60% of these, though only 1.2-5% of all pediatric neoplasms.
  • Malignant tumors include epithelial (hepatoblastoma, hepatocellular carcinoma) and mesenchymal types.

Purpose of the Study:

  • To review the primary malignant epithelial tumors of the liver in children.
  • To provide an overview of hepatoblastoma and hepatocellular carcinoma in pediatric populations.

Main Methods:

  • Literature review focusing on primary hepatic tumors in children.
  • Emphasis on malignant epithelial neoplasms: hepatoblastoma and hepatocellular carcinoma.
  • Exclusion of benign tumors and rarer mesenchymal malignancies.

Main Results:

  • Malignant tumors are more prevalent than benign ones in pediatric liver neoplasms.
  • Hepatoblastoma and hepatocellular carcinoma are the primary epithelial malignancies.
  • Vascular tumors, mesenchymal hamartomas, hepatic adenomas, and focal nodular hyperplasia are common benign types.

Conclusions:

  • Malignant epithelial tumors, specifically hepatoblastoma and hepatocellular carcinoma, are a significant concern in pediatric liver oncology.
  • Understanding these distinct tumor types is crucial for accurate diagnosis and treatment planning in children.