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Failure to thrive associated with renal disease.

J Friedman, J E Lewy

    Pediatric Annals
    |November 1, 1978
    PubMed
    Summary

    Failure to thrive, characterized by reduced growth, is common in chronic renal failure. Key causes include renal osteodystrophy, malnutrition, and altered hormone function, not anemia.

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    Area of Science:

    • Pediatrics
    • Nephrology
    • Endocrinology

    Background:

    • Failure to thrive (FTT) is a syndrome of poor growth, often seen in children with chronic kidney disease (CKD).
    • Recurrent urinary tract infections and tubular disorders can also present with FTT.
    • Understanding FTT in renal disease is crucial for pediatric growth management.

    Purpose of the Study:

    • To identify the primary causes of growth failure in pediatric patients with renal disease.
    • To elucidate the relationship between renal dysfunction and failure to thrive.
    • To differentiate direct and indirect contributors to growth impairment in this population.

    Main Methods:

    • Review of clinical data and literature on pediatric patients experiencing failure to thrive.
    • Analysis of factors associated with growth deficits in chronic renal failure, urinary tract infections, and tubular disorders.
    • Correlation of specific conditions like renal osteodystrophy and malnutrition with growth outcomes.

    Main Results:

    • Chronic renal failure is a common condition associated with failure to thrive.
    • Renal osteodystrophy, protein-calorie malnutrition, and glucocorticoid use are significant causes of growth failure.
    • Altered hormone pathways and acidosis are implicated, while anemia and hypos-thenuria play minor roles.

    Conclusions:

    • Failure to thrive in pediatric renal disease is multifactorial.
    • Addressing renal osteodystrophy, malnutrition, and hormonal imbalances is key to improving growth.
    • Further research into hormonal and metabolic derangements in pediatric renal growth failure is warranted.

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