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Related Experiment Videos

Oxacillin-induced tissue necrosis.

L A Fromm1, D L Graham

  • 1Department of Pharmacy, St. Vincent Hospital, Worcester, MA 01604, USA.

The Annals of Pharmacotherapy
|October 26, 1999
PubMed
Summary
This summary is machine-generated.

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Oxacillin at 50 mg/mL can cause tissue necrosis from extravasation, even with recommended dilution. Lower concentrations or avoiding infusion pumps may prevent this rare but serious antibiotic side effect.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Antibiotic Therapy

Background:

  • Oxacillin is a penicillinase-resistant penicillin antibiotic.
  • Extravasation injuries from peripheral IV infusions can lead to tissue damage.
  • Recommended guidelines for drug dilution and administration are crucial for patient safety.

Observation:

  • A case of oxacillin-induced tissue necrosis occurred in a 79-year-old woman despite adherence to recommended concentration guidelines.
  • The extravasation event happened after the second postoperative dose of oxacillin administered via peripheral infusion pump.
  • A dime-sized area of necrosis was observed at the heparin-lock insertion site.

Findings:

  • The concentration of oxacillin (50 mg/mL) may play a significant role in the severity of tissue damage following extravasation.

Related Experiment Videos

  • This case highlights a potential risk not fully described in previous reports of oxacillin-induced necrosis.
  • Drug concentration is a critical factor in assessing the tissue toxicity potential of antibiotics during extravasation.

    • Implications:

    • Using less concentrated oxacillin preparations may mitigate the risk of tissue necrosis.
    • Avoiding peripheral infusion pump administration for oxacillin could be a preventive measure.
    • Identifying patients at higher risk for adverse reactions to oxacillin is essential for safe clinical practice.