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Related Experiment Videos

Menstrual migraine.

S D Silberstein1

  • 1Jefferson Headache Center and Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA.

Journal of Women'S Health & Gender-Based Medicine
|October 26, 1999
PubMed
Summary
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Menstrual migraine, linked to estrogen fluctuations, affects many women. Effective treatments include NSAIDs, triptans, and preventive hormonal therapies for severe cases.

Area of Science:

  • Neurology
  • Gynecology
  • Endocrinology

Background:

  • Hormonal changes throughout a woman's life cycle significantly influence migraine patterns.
  • Menstrual migraine is a common subtype, with reported frequencies as high as 60%-70%.

Purpose of the Study:

  • To review the pathophysiology and treatment strategies for menstrual migraine.
  • To differentiate between true menstrual migraine and menstrually triggered migraine.

Main Methods:

  • Literature review of clinical experience and established treatment guidelines.
  • Analysis of the role of estrogen withdrawal in migraine pathogenesis.
  • Summary of acute and preventive treatment options.

Main Results:

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  • Estrogen withdrawal during menstruation is a likely trigger for migraine in susceptible women.
  • Effective acute treatments include NSAIDs, dihydroergotamine, triptans, and combination analgesics.
  • Preventive strategies range from continuous prophylaxis to perimenstrual short-term treatment and hormonal therapy.

    • Conclusions:

    • Menstrual migraine management requires understanding hormonal influences and tailored treatment approaches.
    • Hormonal therapy may be indicated for severe, refractory cases of menstrual migraine.