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Related Experiment Videos

Low environmental selenium availability as an additional determinant for goiter in East Java, Indonesia?

J Untoro1, M Ruz, R Gross

  • 1SEAMEO-TROPMED, Jakarta, Indonesia.

Biological Trace Element Research
|October 27, 1999
PubMed
Summary

Iodine deficiency causes goiter in Indonesia, but pockets persist despite iodized salt. This study investigates if low environmental selenium (Se) levels contribute to persistent goiter prevalence.

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Area of Science:

  • Environmental Health
  • Nutritional Science
  • Endocrinology

Background:

  • Goiter, a visible sign of iodine deficiency, remains prevalent in Indonesia despite mandatory salt iodization since 1994.
  • Persistent goiter hotspots suggest other contributing factors beyond iodine deficiency.
  • Selenium (Se) deficiency is hypothesized as a potential co-factor in goiter development.

Purpose of the Study:

  • To assess environmental selenium levels in Indonesian regions with high goiter prevalence.
  • To investigate the relationship between environmental selenium and goiter rates in school children.

Main Methods:

  • Studied 511 school children for goiter via palpation and ultrasound.
  • Collected 99 chicken eggs from 11 villages to determine selenium content in yolk and white using neutron activation analysis.

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Main Results:

  • Selenium concentrations in egg yolk ranged from 0.15 to 1.52 microg/g; in egg white, from 0.18 to 2.97 microg/g.
  • Goiter prevalence varied widely: 18.4%–70% by palpation and 0%–100% by ultrasound.
  • Inconsistent goiter measurements between methods were observed.

Conclusions:

  • The study highlights geographical variations in environmental selenium and goiter prevalence.
  • Inconsistencies in goiter assessment methods complicate direct correlations.
  • Further research is needed to confirm if low environmental selenium is an additional factor contributing to persistent goiter in Indonesia.