Acute hepatitis induced by greater celandine (Chelidonium majus)
Summary
This summary is machine-generated.Herbal remedies like greater celandine (Chelidonium majus) can cause acute hepatitis. Discontinuation of the herb led to recovery in all patients, highlighting its hepatotoxic potential.
Area Of Science
- Hepatology
- Pharmacology
- Herbal Medicine Research
Background
- Conventional drugs are known for hepatotoxicity, while herbal medicines are often perceived as safe.
- Greater celandine (Chelidonium majus) is commonly used for gastric and biliary issues.
Observation
- Ten cases of acute hepatitis linked to greater celandine preparations were observed over two years.
- Hepatitis presentations ranged from mild to severe, with five patients experiencing significant cholestasis.
Findings
- All other potential causes of liver disease were ruled out through comprehensive testing and biopsy.
- Liver damage was consistent with drug-induced injury, and all patients recovered within 2-6 months after stopping greater celandine.
- One patient experienced a relapse of hepatitis upon unintentional re-exposure (rechallenge).
Implications
- Greater celandine should be recognized as a potential cause of acute cholestatic hepatitis.
- This herb may account for a notable percentage of unexplained hepatitis cases.
- Clinicians should consider greater celandine use when evaluating patients with acute liver injury.
View abstract on PubMed