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Acute hepatitis induced by greater celandine (Chelidonium majus).

J Benninger1, H T Schneider, D Schuppan

  • 1Department of Medicine I, Friedrich-Alexander-University Erlangen-Nuernberg, Erlangen, Germany. johannes.bennnger@med1.med.uni-erlangen.de

Gastroenterology
|October 27, 1999

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View abstract on PubMed

Summary
This summary is machine-generated.

Related Concept Videos

  • Chemical Sciences
  • Medicinal And Biomolecular Chemistry
  • Molecular Medicine
  • Acute Hepatitis Induced By Greater Celandine (chelidonium Majus).

    • Herbal remedies like greater celandine (Chelidonium majus) can cause acute hepatitis, contrary to popular belief. This study identified 10 cases, highlighting the need for caution with herbal medicine use.

    Area of Science:

    • Hepatology
    • Herbal Medicine Safety
    • Toxicology

    Background:

    • Conventional drugs are known hepatotoxins, while herbal medicines are often perceived as safe.
    • Greater celandine (Chelidonium majus) is commonly used for gastrointestinal and biliary issues.

    Observation:

    • Ten cases of acute hepatitis linked to greater celandine preparations were observed over two years.
    • Hepatitis presentations ranged from mild to severe, with five patients exhibiting significant cholestasis.

    Findings:

    • All other potential causes of liver disease were ruled out through comprehensive testing and biopsy.
    • Discontinuation of greater celandine led to rapid patient recovery within 2-6 months.
    • One patient experienced a relapse upon unintentional re-exposure, confirming the herb's role.

    Implications:

    • Greater celandine should be recognized as a potential cause of acute cholestatic hepatitis.
    • This herb may account for a notable percentage of unexplained hepatitis cases.
    • Healthcare providers and patients should be aware of the hepatotoxic risks associated with greater celandine.

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