Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute ethanol administration impairs spatial performance while facilitating nonspatial performance in rats.

D B Matthews1, M Ilgen, A M White

  • 1Department of Psychology, Miami University, Oxford, Ohio, 45056, USA. dougmat@med.unc.edu

Neurobiology of Learning and Memory
|October 28, 1999
PubMed
Summary

Acute ethanol administration impairs spatial learning and memory in rats, similar to hippocampal lesions. Ethanol reduced place-based navigation, instead increasing cue-based choices, demonstrating dose-dependent effects on memory retrieval.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age modifies the effect of ethanol on behavior: Investigations in adolescent, adult and aged rats.

International review of neurobiology·2021
Same author

Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells.

Science immunology·2020
Same author

Correction to Catalyst-Controlled Stereoselective Synthesis Secures the Structure of the Antimalarial Isocyanoterpene Pustulosaisonitrile-1.

The Journal of organic chemistry·2018
Same author

Effects of age on the pharmacokinetics of tramadol and its active metabolite, O-desmethyltramadol following intravenous administration to foals.

Equine veterinary journal·2016
Same author

Abnormal connexin expression in human chronic wounds.

The British journal of dermatology·2015
Same author

Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus.

Journal of neuroscience research·2014

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Cognitive Psychology

Background:

  • Acute ethanol administration causes learning and memory deficits.
  • Hippocampal system lesions also impair spatial learning and memory.
  • Both ethanol and hippocampal lesions can shift behavioral guidance from spatial to cue-based information.

Purpose of the Study:

  • To investigate the effects of acute ethanol administration on spatial and cue-based navigation in rats.
  • To compare the behavioral effects of ethanol with those of hippocampal lesions.
  • To determine the dose-dependent effects of ethanol on memory-guided behavior in a radial arm maze.

Main Methods:

  • Rats were trained on an eight-arm radial arm maze for a food reward in a specific location with distinct cues.

Related Experiment Videos

  • After training, rats received different doses of ethanol (0.0, 1.0, 1.5, or 2.0 g/kg) or saline.
  • The maze was rotated during testing, and approaches to the previously rewarded location and the cued arm were recorded.

    • Main Results:

    • Sober rats showed a bias towards the previously rewarded location.
    • Ethanol administration dose-dependently reduced approaches to the rewarded place.
    • Ethanol increased approaches to the cued arm in its new location, rather than random choices.

    Conclusions:

    • Acute ethanol administration produces learning and memory impairments comparable to hippocampal lesions.
    • Ethanol disrupts the use of spatial information, promoting reliance on distal cues.
    • These findings highlight the shared impact of ethanol and hippocampal damage on spatial navigation and memory processes.