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[The use of sirdalud in cerebral palsy in children]
Insights
Low doses of Sirdalud effectively treated cerebral palsy in children, improving motor, autonomic, and emotional functions without side effects. This study highlights Sirdalud
Area of Science:
- Neurology
- Pediatrics
- Pharmacology
Background:
- Cerebral palsy (CP) is a group of movement disorders present from birth or early childhood.
- Diplegic CP, a severe form, significantly impacts motor function.
- Effective and safe therapeutic options for managing CP symptoms are crucial.
Purpose of the Study:
- To evaluate the efficacy and safety of Sirdalud monotherapy in children with severe diplegic cerebral palsy.
- To assess the impact of Sirdalud on motor, autonomic, and mental spheres in pediatric CP patients.
- To investigate the effects of Sirdalud on neurophysiological parameters in children with CP.
Main Methods:
- A cohort of 30 diplegic children with severe cerebral palsy participated.
- Sirdalud was administered as monotherapy for 2-6 weeks at low doses (1mg or 2mg thrice daily).
- Electroneuromyographic analysis was performed to assess neurophysiological changes.
Main Results:
- Positive effects were observed across motor, autonomic, and mental (emotional) functions.
- Sirdalud demonstrated high efficacy in patients post-orthopedic-surgical treatment.
- Electroneuromyographic analysis revealed decreased synergistic tonic activity and improved supraspinal influences and segmental interaction.
Conclusions:
- Low-dose Sirdalud monotherapy is effective in managing severe cerebral palsy in children.
- Sirdalud treatment resulted in significant improvements in various functional spheres without reported side effects.
- The findings support Sirdalud as a safe and beneficial therapeutic agent for pediatric cerebral palsy.
Abstract:
30 diplegic children (mean age 11.3 +/- 2.8 years old) with severe form of cerebral palsy received sirdalud monotherapy during 2-6 weeks (1 mg for children under 10 years old and 2 mg for older children, 3 times daily). Positive effects were determined in motor, autonomic and mental (emotional) spheres. Sirdalud was also very effective in patients after orthopedic-surgical treatment. Electroneuromyographic analysis showed the decrease of the synergic tonic activity, as well as the improvement of the supraspinal influences and the segmental interaction. Thus, the small doses of sirdalud are effective without side effects in children with cerebral palsy.