Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genes as gerontological variables: uniform genotypes.

G E McClearn1, S M Hofer

  • 1Center for Developmental and Health Genetics, The Pennsylvania State University, University Park 16802, USA.

Neurobiology of Aging
|October 28, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocol for the Brain Health Support Program Study of the Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP): A Prospective 12-Month Intervention Study.

The journal of prevention of Alzheimer's disease·2023
Same author

Decline in Memory, Visuospatial Ability, and Crystalized Cognitive Abilities in Older Adults: Normative Aging or Terminal Decline?

Journal of aging research·2017
Same author

Maximizing the Usefulness of Data Obtained with Planned Missing Value Patterns: An Application of Maximum Likelihood Procedures.

Multivariate behavioral research·2016
Same author

Quantitative trait loci and psychopharmacology.

Journal of psychopharmacology (Oxford, England)·2012
Same author

Quantitative trait loci and psychopharmacology: response to commentaries.

Journal of psychopharmacology (Oxford, England)·2012
Same author

Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice.

Genes, brain, and behavior·2009

Inbred strains offer genetically uniform reference groups for life science research, aiding replication and data accumulation. However, their use requires awareness of limitations in generalizability and co-variation assessment.

Area of Science:

  • Life Sciences
  • Gerontology
  • Genetics

Background:

  • Genetic methods are increasingly vital in life sciences, including gerontology.
  • Inbred strains are fundamental genetic research tools providing near-genetic uniformity.

Purpose of the Study:

  • To highlight the utility of inbred strains as a basic research tool.
  • To discuss the advantages and limitations of using inbred strains in scientific research.

Main Methods:

  • Utilizing successive generations of related matings to achieve genetic uniformity in inbred strains.
  • Leveraging distinct genotypes of different inbred strains as reference groups.

Main Results:

  • Inbred strains provide stable, genetically uniform reference groups for diverse researchers.

Related Experiment Videos

  • Phenotypic differences among strains indicate genetic influence and guide research objectives.
  • The use of inbred strains enhances research replication and data accumulation.

    • Conclusions:

    • Inbred strains are powerful tools offering significant advantages for specific research aims.
    • Limitations include restricted generalizability and constraints on assessing co-variation.
    • Researchers should select appropriate genetic tools, potentially using multiple methods, based on study objectives.