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Enteroviruses and myocardial infarction.

M Roivainen1

  • 1Enterovirus Laboratory, National Public Health Institute, Helsinki, Finland.

American Heart Journal
|October 28, 1999
PubMed
Summary

Enteroviral infections may increase the risk of myocardial infarction (heart attack), particularly in younger, normocholesteremic men. Past enterovirus infections, indicated by high antibody levels, are linked to future cardiac events.

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Atherosclerosis pathogenesis may involve microbial infections.
  • Enteroviral infections are investigated as potential cardiac event risk factors.

Purpose of the Study:

  • To evaluate the role of enteroviral infections in cardiac events.
  • To determine if enterovirus antibodies are associated with myocardial infarction risk.

Main Methods:

  • Nested case-control design in 3 large prospective population studies.
  • Analysis of enterovirus-specific immunoglobulin G antibodies in baseline sera.
  • Comparison of antibody levels between myocardial infarction cases and matched controls.

Main Results:

  • Elevated enterovirus antibodies were found in cases versus controls in 2 of 3 studies.
  • High enterovirus antibody levels independently predicted future cardiac events.
  • Increased risk was observed in younger men and those with low serum cholesterol.

Conclusions:

  • Past enterovirus infections, suggested by high antibody levels, increase myocardial infarction risk.
  • The association appears significant in normocholesteremic men.

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