Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

What is primary lateral sclerosis?

M Swash1, J Desai, V P Misra

  • 1Department of Neurology, St. Bartholomew's and The Royal London School of Medicine and Dentistry, The Royal London Hospital, London, UK. mswash@mds.qmw.ac.uk

Journal of the Neurological Sciences
|December 14, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomised study of encorafenib, cetuximab, and FOLFIRI versus FOLFIRI with or without bevacizumab in BRAF V600E-mutant colorectal cancer: BREAKWATER Cohort 3.

Annals of oncology : official journal of the European Society for Medical Oncology·2026
Same author

Wasted leg syndrome: An atypical slowly-progressive form of lower motor neuron disease.

Revue neurologique·2022
Same author

Quality of life with encorafenib plus cetuximab with or without binimetinib treatment in patients with BRAF V600E-mutant metastatic colorectal cancer: patient-reported outcomes from BEACON CRC.

ESMO open·2022
Same author

Management of adverse events from the treatment of encorafenib plus cetuximab for patients with BRAF V600E-mutant metastatic colorectal cancer: insights from the BEACON CRC study.

ESMO open·2021
Same author

Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Correction to: Economic evaluation of AbobotulinumtoxinA vs OnabotulinumtoxinA in real-life clinical management of cervical dystonia.

Journal of clinical movement disorders·2020
Same journal

Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

Journal of the neurological sciences·2026
Same journal

Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

Journal of the neurological sciences·2026
Same journal

Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

Journal of the neurological sciences·2026
Same journal

Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

Journal of the neurological sciences·2026
Same journal

Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

Journal of the neurological sciences·2026
Same journal

Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

Journal of the neurological sciences·2026
See all related articles

Primary lateral sclerosis (PLS) is a rare upper motor neuron disorder with uncertain classification. This review clarifies its history, diagnosis, and relationship to amyotrophic lateral sclerosis (ALS).

Area of Science:

  • Neurology
  • Neurodegenerative Diseases

Background:

  • Primary lateral sclerosis (PLS) is a rare disorder affecting upper motor neurons.
  • Its exact classification and relationship with other motor neuron diseases, particularly amyotrophic lateral sclerosis (ALS), remain unclear.

Observation:

  • Diagnostic criteria for PLS have been proposed.
  • The historical context and overlapping conditions with other motor neuron diseases are discussed.

Findings:

  • Two patient cases illustrate the clinical, laboratory, and neurophysiological characteristics of PLS.
  • The current understanding of PLS is presented through these case studies.

Implications:

  • Clarifying the nosological status of PLS is crucial for accurate diagnosis and patient management.

Related Experiment Videos

  • Further research into PLS and its differentiation from ALS is warranted.