Related Experiment Videos
Total Synthesis of (+/-)-Gelsemine
1Department of Chemistry, University of California, 516 Rowland Hall, Irvine, CA 92697-2025 (USA).
Angewandte Chemie (International Ed. in English)
|December 14, 1999
Abstract:
A complex molecular reorganization (1-->2), a sequential anionic aza-Cope rearrangement and Mannich cyclization, and an unprecedented intramolecular Heck reaction of the tetrasubstituted double bond of a vinylogous carbamate are key steps in a new total synthesis of (+/-)-gelsemine (3). MOM=methoxymethyl, DBU=1,8-diazabicyclo[5.4.0]undec-7-ene.