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Regio- and Diastereoselective Aldol Products through Three-Component Coupling Reactions of Difluoroboroxy Fischer
Barluenga1, Rodríguez, Fañanás
1Instituto Universitario de Química Organometálica "Enrique Moles", Unidad Asociada al CSIC, Universidad de Oviedo, Julian Clavería 8, E-33071-Oviedo (Spain).
Angewandte Chemie (International Ed. in English)
|December 14, 1999
Abstract:
The reaction of difluoroboroxy Fischer carbene complexes, vinyl ketones, and aldehydes leads to the regioselective formation of aldol-like products (see reaction scheme). The reaction also shows a high degree of diastereofacial selectivity when chiral aldehydes are used. These results show that this is a very attractive process since the regioselective formation of aldols from nearly symmetrical ketones still remains an unsolved problem.