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Enantioselective Total Synthesis of Avarol and Avarone
Ling1, Xiang, Theodorakis
1Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive #0358, La Jolla, CA 92093-0358 (USA).
Angewandte Chemie (International Ed. in English)
|December 14, 1999
Abstract:
Formation of the C11-C1' bond through application of Barton's radical decarboxylation and quinone addition is the cornerstone of a new convergent and concise synthesis of the marine metabolites avarol (1) and avarone (2; see scheme), for which antimitotic, antileukemic, and antiviral effects have been reported.