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[Nicotinic acid and nicotinamide].

M Kobayashi1, S Shimizu

  • 1Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 14, 1999
PubMed
Summary
This summary is machine-generated.

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Niacin, encompassing nicotinic acid and nicotinamide, is vital for preventing pellagra and supporting growth. This essential vitamin plays a key role in crucial metabolic processes like glycolysis and respiration.

Area of Science:

  • Biochemistry
  • Human Nutrition

Context:

  • Niacin, comprising nicotinic acid and nicotinamide, is an essential vitamin crucial for human and animal health.
  • It is widely available in natural food sources such as liver, fish, yeast, and cereal grains.

Purpose:

  • To highlight the significance of niacin (nicotinic acid and nicotinamide) as the antipellagra vitamin.
  • To underscore its essential role in preventing and curing pellagra in humans.
  • To detail its function as a precursor to vital coenzymes NAD and NADP.

Summary:

  • Niacin is essential for growth and health in animals and prevents pellagra in humans.
  • Nicotinamide serves as a precursor for coenzymes NAD and NADP, fundamental to cellular energy metabolism.
  • Key metabolic pathways involving niacin include glycolysis, fatty acid synthesis, and respiration.

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Impact:

  • Niacin's role in preventing pellagra and supporting metabolic functions is critical for public health.
  • Understanding niacin's involvement in metabolic pathways can inform nutritional guidelines and disease management.
  • Niacin deficiency or metabolic disorders associated with its pathways, such as Hartnup disease, highlight its importance in human health.