[The current state on development of novel vitamin derivatives]

In this review, we outline the current state on developments of novel vitamin A, C and D derivatives. We focused on the topics obtained with these novel vitamin A derivatives in relation to cell differentiation, apoptosis and gene regulation. As for vitamin D derivatives, the results obtained on cell differentiation and calcium metabolism were summarized. Lastly, we described some stable ascorbates, and further introduced stable (AA-2G) and lipophilic (6-Acyl-AA-2G) derivatives which have been recently developed in our laboratory. Both of them were demonstrated by us to express vitamin C activity in vivo.