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Related Experiment Videos

Complement membrane attack complex (C5b-9) mediates interstitial disease in experimental nephrotic syndrome.

M Nangaku1, J Pippin, W G Couser

  • 1Department of Medicine, University of Washington, Seattle, USA.

Journal of the American Society of Nephrology : JASN
|November 30, 1999
PubMed
Summary

The complement system

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Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Proteinuria can lead to tubulointerstitial disease and progressive kidney function loss.
  • The role of complement activation products in this process is not fully understood.

Purpose of the Study:

  • To investigate the role of C5b-9 in complement-mediated damage to renal tubular cells caused by proteinuric urine.

Main Methods:

  • Proteinuria was induced in normocomplementemic and C6-deficient rats.
  • Histologic analysis and markers of tubular damage (vimentin, osteopontin, proliferating cell nuclear antigen) were assessed.

Main Results:

  • Complement-sufficient rats showed more severe tubulointerstitial disease than C6-deficient rats.

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  • Tubular damage markers and extracellular matrix accumulation were higher in complement-sufficient animals.

    • Conclusions:

    • C6 and C5b-9 play a significant role in the pathogenesis of non-immunologic tubulointerstitial injury induced by proteinuria.
    • Preventing C5b-9 formation may slow kidney function decline in proteinuric conditions.