Related Experiment Videos
Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine
1Departments of Medicine and Biochemistry, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. dcohen@aecom.yu.edu
Biochimica Et Biophysica Acta
|November 5, 1999
Abstract:
Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. We have cloned a cDNA encoding the human ortholog of PC-TP and have determined its tissue-specific expression as well as genomic organization. Radiation hybrid mapping localized the human gene, PCTP, to chromosome 17q21-22 and PCR-based single strand conformation polymorphism analysis of an interspecific backcross assigned mouse Pctp to the region of syntenic conservation on chromosome 11.