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Related Concept Videos

Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
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Related Experiment Video

Updated: Apr 5, 2026

A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation
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A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation

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Vitamin D and Hip Fracture.

Pfeifer1, Minne

  • 1Institute of Clinical Osteology 'Gustav Pommer' and Clinic 'Der Fürstenhof', Bad Pyrmont, Germany.

Trends in Endocrinology and Metabolism: TEM
|November 5, 1999
PubMed
Summary

Hip fractures pose a global health challenge, but prevention is possible. Combining calcium (Ca2+) and vitamin D supplementation, bisphosphonate treatment, and hip protectors can significantly reduce fracture risk in the elderly.

Area of Science:

  • Gerontology
  • Orthopedics
  • Public Health

Background:

  • Hip fractures represent a significant and growing global public health concern.
  • Projected increases in hip fractures, from 1.26 million in 1990 to 4.5 million by 2050, highlight the urgent need for effective prevention strategies.

Purpose of the Study:

  • To review available preventive strategies for hip fractures.
  • To assess the efficacy of calcium and vitamin D supplementation, bisphosphonate therapy, and hip protectors in reducing hip fracture incidence.

Main Methods:

  • Review of existing literature on hip fracture prevention.
  • Analysis of the impact of calcium and vitamin D on bone quality and fall risk.
  • Evaluation of bisphosphonate alendronate's effect on bone strength.

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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

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Last Updated: Apr 5, 2026

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  • Assessment of hip protectors' energy-absorbing capabilities during falls.
  • Main Results:

    • Vitamin D and calcium supplementation reduced hip fracture risk by 43% in vitamin D-insufficient elderly individuals.
    • Bisphosphonate alendronate treatment resulted in a 51% reduction in hip fracture risk.
    • Hip protectors demonstrated a 56% reduction in hip fracture risk by absorbing fall impact energy.

    Conclusions:

    • Preventive strategies, including nutritional supplementation, pharmacotherapy, and protective devices, are available and effective.
    • Combining calcium and vitamin D, bisphosphonates, and hip protectors offers a promising approach to substantially decrease future hip fracture incidence.