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Related Experiment Videos

Volume calibration alone may be misleading.

G van den Boom1, L M van der Star, H Folgering

  • 1Department of General Practice and Social Medicine, University of Nijemegen, The Netherlands. G.vanden-Boom@hsv.kun.nl

Respiratory Medicine
|October 30, 1999
PubMed
Summary

Volume calibration of spirometers using a 3000 ml syringe may not guarantee accurate forced expiratory volume in 1 second (FEV1) results. Regular biological calibration and comparing data between spirometers are recommended for reliable diagnostic spirometry.

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Area of Science:

  • Pulmonary Function Testing
  • Medical Device Calibration
  • Respiratory Diagnostics

Background:

  • Spirometry use is expanding beyond laboratories into general practice and occupational medicine.
  • Volume calibration with a 3000 ml syringe is a common method for ensuring spirometer data validity in non-laboratory settings.
  • Sophisticated calibration equipment for forced maneuvers is often unavailable in these environments.

Purpose of the Study:

  • To assess if volumetric calibration guarantees valid and comparable spirometric results.
  • To evaluate the accuracy of spirometers calibrated with a 3000 ml syringe.
  • To determine the reliability of spirometric data in non-laboratory settings.

Main Methods:

  • Two portable spirometers were calibrated using a 3000 ml syringe per American Thoracic Society (ATS) guidelines over 8 days.

Related Experiment Videos

  • Comparisons included: 1) inter-spirometer FEV1 data from 43 volunteers using Bland and Altman plots, and 2) comparison to a computer-driven syringe (CDS) gold standard.
  • ATS criteria for volume calibration were met by both spirometers.

    • Main Results:

    • Despite meeting ATS volume calibration criteria, a systematic, volume-dependent difference in FEV1 was observed between the two spirometers (mean difference: 289 ml, 8.6%).
    • This systematic difference was confirmed through comparison with the CDS.
    • Volume calibration alone can be misleading, failing to guarantee accurate forced maneuver data.

    Conclusions:

    • Volumetric calibration meeting ATS criteria does not ensure accurate spirometric measurements.
    • In the absence of advanced calibration tools like CDS, regular biological calibration is crucial.
    • Comparing paired data from multiple spirometers is recommended for enhanced accuracy in non-laboratory settings.