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Application of AdvaSeal for acute aortic dissection: experimental study
K Tanaka1, S Takamoto, T Ohtsuka
1Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Japan. tanakak-tho@h.u-tokyo.ac.jp
The Annals of Thoracic Surgery
|October 30, 1999
Summary
A novel sealant, AdvaSeal, effectively closed the false lumen in acute aortic dissection in dogs. This surgical sealant achieved good hemostasis and fusion of dissected aortic layers, offering a promising treatment option.
Area of Science:
- Cardiovascular Surgery
- Biomaterials Science
Background:
- Intractable hemorrhage is a significant complication in surgical repair of acute aortic dissection.
- A new sealant, AdvaSeal, was investigated for its potential to manage this complication.
Purpose of the Study:
- To evaluate the efficacy of AdvaSeal in closing the false channel of acute aortic dissection.
- To assess the sealant's hemostatic properties and tissue adhesion in a canine model.
Main Methods:
- Acute descending aortic dissection was surgically induced in 12 mongrel dogs.
- AdvaSeal was applied to the false cavity and suture line in 7 dogs (treated group).
- Control group (5 dogs) received no sealant treatment; specimens were harvested after 2 weeks.
Main Results:
- AdvaSeal demonstrated effectiveness in wet conditions, facilitating easy hemostasis during surgery.
- All treated false cavities were thrombosed without adverse sealant-related effects.
- Control group false lumina remained patent, indicating lack of spontaneous closure.
Conclusions:
- AdvaSeal proved effective due to its performance on wet tissue and strong adhesiveness.
- The sealant facilitated good hemostasis and closure of the false lumen in acute aortic dissection.
- AdvaSeal presents as an easy and efficacious option for treating acute aortic dissection.