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Updated: Jul 24, 2026
08:19
Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
Micronised transdermal progesterone and endometrial response.
Lancet (London, England)
|October 30, 1999
Summary
Sequential transdermal progesterone did not adequately raise blood levels or stimulate endometrial changes when given with continuous transdermal oestrogen. This hormonal therapy approach was insufficient for achieving desired endometrial secretory response.
Area of Science:
- Endocrinology
- Reproductive Biology
- Gynecology
Background:
- Continuous transdermal oestrogen is used for hormone replacement therapy.
- Progesterone is crucial for preparing the endometrium for implantation.
- Optimizing transdermal progesterone delivery alongside oestrogen requires further investigation.
Purpose of the Study:
- To evaluate the efficacy of sequential transdermal progesterone in achieving adequate endometrial transformation.
- To assess the impact of this regimen on circulating progesterone levels.
Main Methods:
- Administration of sequential transdermal progesterone with continuous transdermal oestrogen.
- Monitoring of circulating blood progesterone concentrations.
- Assessment of endometrial response (histological examination for secretory changes).
Main Results:
- Transdermal progesterone failed to significantly increase circulating progesterone concentrations.
- The regimen was insufficient to induce a secretory response in the proliferating endometrium.
Conclusions:
- Sequential transdermal progesterone, when combined with continuous transdermal oestrogen, is not an effective method for achieving endometrial secretory changes.
- Alternative or optimized delivery methods for transdermal progesterone may be necessary.
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