Behavioral profile of quinpirole in agonistic encounters between male mice

Most neuroleptic drugs that act as dopaminergic D2 receptor antagonists are effective antiaggressive agents. Although the action of D2 antagonists on aggression has been extensively documented, little is known about the influence of D2 agonists. This study was designed to examine the effect of quinpirole (0.2, 0.4 and 0.8 mg/kg i.p.), a potent agonist at D2 receptors,on agonistic behavior elicited by isolation in male mice. Individually housed mice were exposed to anosmic standard opponents 30 min after drug administration and encounters were videotaped and evaluated using an ethologically based analysis. Quinpirole exhibited an ethopharmacological profile characterized by a selective decrease in offensive behaviors (threat and attack) at low doses (0.2 mg/kg) without affecting motility or exploratory behaviors. This action could be related to the activation of presynaptic D2 receptors. In contrast, at higher doses (0.8 mg/kg), this drug produced a behavioral pattern defined by a significant increase in defense/submission and avoidance/fleeing as well as a reduction in digging and social investigation behaviors suggesting that it could also show anxiogenic-like properties.