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[Molecular mimicry of bacteria as a factor in bacterial pathogenicity]
1Instytut Immunologii i Terapii Doświadczalnej PAN, Wrocławiu.
Abstract:
Structural and functional homology between bacterial proteins and host antigens, called molecular mimicry, is considered as significant pathogenic factor involved in several autoimmune diseases. The most important examples of this phenomenon reviewed in this work, involve rheumatic fever, Graves' disease, ankylosing spondylitis, Reiter's syndrome and rheumatic arthritis caused by infections with Streptococcus, Yersinia, Klebsiella, Escherichia coli, respectively.
Insights
Molecular mimicry, where bacterial proteins resemble host antigens, is a key factor in autoimmune diseases. This review highlights its role in conditions like rheumatic fever and arthritis linked to specific bacterial infections.
Area of Science:
- Immunology
- Microbiology
- Pathogenesis