Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Ticlopidine-induced lymphocytic colitis].

I Rosa¹, S Nahon, C Cohen

¹Service d'Hépato-Gastroentérologie, Centre Hospitalier Intercommunal de Créteil.

Annales De Medecine Interne

|November 2, 1999

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Does the density of lymphatic vascular space invasion affect the prognosis of stage Ib and IIA node negative carcinoma of the cervix?

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2003

Same author

SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation.

The Journal of pharmacology and experimental therapeutics·2003

Same author

Refinement of the Episkin protocol for the assessment of acute skin irritation of chemicals: follow-up to the ECVAM prevalidation study.

Toxicology in vitro : an international journal published in association with BIBRA·2002

Same author

SR141716, a central cannabinoid (CB(1)) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats.

Behavioural pharmacology·2002

Same author

Hepatocellular carcinoma and markers of apoptosis (bcl-2, bax, bcl-x): prognostic significance.

Applied immunohistochemistry & molecular morphology : AIMM·2002

Same author

Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor.

Proceedings of the National Academy of Sciences of the United States of America·2002

This study reports a rare case of microscopic colitis with both lymphocytic and collagenous features. Ticlopidine use was linked to chronic diarrhea, resolving upon drug discontinuation, suggesting a causal relationship.

Area of Science:

Gastroenterology
Pathology

Background:

Microscopic colitis encompasses conditions like lymphocytic colitis and collagenous colitis, characterized by chronic diarrhea and specific histological findings.
The exact etiology remains unknown, but associations with immune disorders and certain medications (NSAIDs, veinotonics) are noted.

Observation:

A 65-year-old male presented with chronic diarrhea.
The patient was diagnosed with a rare form of microscopic colitis combining features of both lymphocytic and collagenous colitis.
Diarrhea onset coincided with ticlopidine intake and resolved upon its cessation, recurring with re-administration.

Findings:

Histological examination revealed features consistent with both lymphocytic colitis and collagenous colitis.
Ticlopidine was identified as a potential causative agent for the patient's chronic diarrhea.

Related Experiment Videos

Cessation of ticlopidine led to improvement in histological damage associated with lymphocytic colitis.

Implications:

This case highlights ticlopidine as a potential trigger for drug-induced microscopic colitis, specifically the lymphocytic subtype.
It underscores the importance of considering medication history in patients presenting with unexplained chronic diarrhea.
Further research may elucidate the mechanisms by which ticlopidine induces colonic inflammation.