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Related Experiment Videos

[Sydenham's chorea in children].

N Ghram1, C Allani, B Oudali

  • 1Service de pédiatrie, urgences et consultations externes, hôpital d'enfants de Tunis.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|November 2, 1999
PubMed
Summary
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Sydenham's chorea, a childhood neurological disorder, remains present in Tunisia despite antibiotic use. While most cases resolve, a minority develop chronic symptoms, highlighting the need for ongoing surveillance and treatment strategies for this streptococcal sequela.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Rheumatology

Background:

  • Sydenham's chorea, a significant cause of acquired chorea in children, has seen a decline in incidence due to antibiotic therapy.
  • Understanding its current prevalence and clinical spectrum is crucial, especially in regions with varying healthcare access.

Purpose of the Study:

  • To determine the hospital incidence of Sydenham's chorea in Tunisia.
  • To describe the clinical characteristics, treatment, and outcomes of affected children.

Main Methods:

  • A retrospective analysis of 15 Sydenham's chorea cases treated between 1987 and 1997.
  • Data collected included patient demographics, medical history, clinical presentation, treatment regimens, and follow-up outcomes.

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Main Results:

  • The study identified 15 cases, representing a hospital incidence of 5.6 per 1000 children, with a mean age of 10.5 years.
  • Commonly observed symptoms included choreic movements (often asymmetrical), psychological disorders, and hypotonia. Rheumatic carditis was present in 3 patients.
  • While initial treatment with haloperidol, steroids, and antibiotics led to symptom resolution in all cases within three months, three patients relapsed, with two developing chronic sequelae.

Conclusions:

  • Sydenham's chorea, though less common, is still encountered in Tunisia.
  • No malignant forms were observed, but chronic cases with sequelae occurred in 2 out of 15 patients.
  • The study found no correlation between the outcome and secondary prevention of streptococcal infections.