Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Partial patellectomy induces a decrease in the proteoglycan content in the remaining patellar articular cartilage. An

K S Leung1, L Qin, M C Leung

  • 1Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong.

Clinical and Experimental Rheumatology
|November 2, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Olfactory enrichment - effects of odorised straw on exploratory behaviour, straw engagement, and play in finishing pigs.

Animal : an international journal of animal bioscience·2026
Same author

[Systemic necrotizing lymphadenitis: a case report].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2025
Same author

Compositional data modeling of high-dimensional single cell RNA-seq (CoDA-hd): its advantages over commonly used normalization approaches.

Journal of translational medicine·2025
Same author

[Prognostic factors of immunosuppression therapy combined with eltrombopag in the treatment of childhood severe aplastic anemia].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2024
Same author

[Three cases of aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2023
Same author

[Altered dynamics of brain spontaneous activity in betel quid dependence chewers].

Zhonghua yi xue za zhi·2022
Same journal

The expanded cardiovascular risk prediction score as a cardiovascular mortality predictor in rheumatoid arthritis.

Clinical and experimental rheumatology·2026
Same journal

Rising overweight and obesity in Swiss psoriatic arthritis patients, 2007-2022: a nationwide registry-population comparison.

Clinical and experimental rheumatology·2026
Same journal

Clinical features and gastrointestinal bleeding risk factors in IgA vasculitis patients: a retrospective study in a large volume centre.

Clinical and experimental rheumatology·2026
Same journal

Reply to the comment on: The microbiota in axial spondyloarthritis: what have we learned from Mendelian randomisation studies?

Clinical and experimental rheumatology·2026
Same journal

Comprehensive evaluation of bone structural and microarchitectural changes in rheumatoid arthritis treated with baricitinib using HR-pQCT, imaging, and biomarker analyses.

Clinical and experimental rheumatology·2026
Same journal

Tracking interstitial lung disease in systemic sclerosis: integrating lung magnetic resonance imaging into a clinically oriented multimodal follow-up strategy.

Clinical and experimental rheumatology·2026
See all related articles

Partial patellectomy in rabbits reduced proteoglycan content in remaining knee cartilage. Scar tissue metaplasia may offer a protective response against further cartilage loss and osteoarthritis development.

Area of Science:

  • Orthopedics
  • Biochemistry
  • Histology

Background:

  • Partial patellectomy is a surgical procedure that can affect knee joint biomechanics.
  • Proteoglycans (PG) are crucial components of articular cartilage, providing hydration and load-bearing capacity.
  • Alterations in PG content are associated with cartilage degeneration and osteoarthritis.

Purpose of the Study:

  • To investigate the impact of unilateral partial patellectomy on proteoglycan content in the remaining patellar articular cartilage.
  • To analyze the distribution of proteoglycan changes.
  • To explore potential compensatory mechanisms in the healing interface.

Main Methods:

  • Unilateral partial patellectomy was performed on 13 rabbits.
  • Sagittal sections of the patella were prepared.

Related Experiment Videos

  • Safranin O staining was used for proteoglycan quantification via imaging analysis.

    • Main Results:

    • A significant decrease in proteoglycan content was observed in the remaining patellar articular cartilage post-surgery.
    • Metaplasia developed in the scar tissue adjacent to the healing interface.
    • These findings suggest a localized depletion of PGs in the operated cartilage.

    Conclusions:

    • Partial patellectomy leads to reduced proteoglycan content in the remaining patellar articular cartilage.
    • Postoperative metaplasia in scar tissue may act as a compensatory mechanism.
    • This response could potentially mitigate further PG loss and prevent osteoarthritis development in the residual cartilage.