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Purification of Hsp104, a Protein Disaggregase
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Purification of Hsp104, a Protein Disaggregase

Published on: September 30, 2011

Intrapolypeptide disulfides in human alphaA-crystallin and their effect on chaperone-like function

M Cherian-Shaw1, J B Smith, X Y Jiang

  • 1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912-2100, USA.

Molecular and Cellular Biochemistry
|November 2, 1999
PubMed
Summary

Aging causes a loss in alpha-crystallin chaperone activity due to protein-protein disulfides (PSSP). Restoring disulfide bonds with glutathione reductase (GR) improved this function in human lenses.

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