Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A thermodynamic model for receptor clustering.

C Guo1, H Levine

  • 1Department of Physics, University of California, San Diego, La Jolla, California 92093-0319, USA.

Biophysical Journal
|November 5, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum: "Highly versatile, two-color setup for high-order harmonic generation using spatial light modulators" [Rev. Sci. Instrum. 95, 073002 (2024)].

The Review of scientific instruments·2026
Same author

Deep learning-based automated assessment of pulmonary artery indices and surgical approach triage for tetralogy of Fallot from multicenter cardiac computed tomography (CT).

Clinical radiology·2026
Same author

The effects of nitrogen and phosphorus fertilization on nutrient resorption in female and male Populus cathayana.

Plant biology (Stuttgart, Germany)·2026
Same author

Rubisco large and small subunits provide insights into allotetraploidy events from the genus Oryza.

Plant biology (Stuttgart, Germany)·2026
Same author

Energy Bunching from Subcycle Ionization Injection in Laser Wakefield Acceleration.

Physical review letters·2026
Same author

Dimensionality of the reinforced superconductivity in UTe<sub>2</sub>.

Nature communications·2025
Same journal

Heterogeneous binding of SARS-CoV2 fusion peptide on complex cellular membranes enhances its fusogenicity.

Biophysical journal·2026
Same journal

Tau protein differentially affects Piezo1 and Kir2.1 channels in brain capillary endothelial cells.

Biophysical journal·2026
Same journal

Emergent Intercellular Junction Stability during Cyclic Tissue Loading.

Biophysical journal·2026
Same journal

Enhanced-Sampling Simulations Reveal Distinct Intermediates in SARS-CoV-2 FSE Pseudoknot Interconversion.

Biophysical journal·2026
Same journal

Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of an infection-critical peptide externalization event.

Biophysical journal·2026
Same journal

Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

Biophysical journal·2026
See all related articles

Ligand binding triggers cell surface receptor clustering, a key step in cellular signaling. Our model explains this cooperative process, revealing a first-order transition that enhances signal robustness.

Area of Science:

  • Biophysics
  • Cellular Biology
  • Theoretical Biology

Background:

  • Intracellular signaling is initiated by ligand-induced clustering of cell surface receptors.
  • Receptor clustering is a cooperative phenomenon influencing signal transduction pathways.
  • Existing research lacks a predictive theoretical framework for receptor cluster formation.

Purpose of the Study:

  • To develop a simple, coarse-grained phenomenological model for ligand-modulated receptor interactions.
  • To analyze the equilibrium properties of receptor clustering using mean-field theory.
  • To explore the implications of the model's predicted transitions on cellular signaling robustness.

Main Methods:

  • Development of a coarse-grained phenomenological model for receptor-ligand interactions.

Related Experiment Videos

  • Application of mean-field theory to determine equilibrium properties of the model.
  • Analysis of phase transitions within the proposed theoretical framework.

    • Main Results:

    • The model successfully describes ligand-modulated receptor interactions and clustering.
    • Mean-field analysis reveals the equilibrium properties of the cooperative clustering process.
    • A first-order phase transition was identified, indicating a switch-like behavior in cluster formation.

    Conclusions:

    • The proposed model provides a simplified yet powerful framework for understanding receptor clustering.
    • The identified first-order transition suggests a mechanism for robust cellular signaling responses.
    • This theoretical approach can bridge molecular interaction data with macroscopic signaling behavior.