Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mapping in the sequencing era.

A Collins1

  • 1University of Southampton, Wessex Human Genetics Institute, Southampton General Hospital, Southampton, UK.

Human Heredity
|November 5, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Klinefelter syndrome in a Holstein-Friesian bull: a case report.

Irish veterinary journal·2026
Same author

Design and evaluation of a custom circulating tumour DNA assay to detect endometrial cancer recurrence.

NPJ precision oncology·2026
Same author

Placement, management and complications associated with peripheral intravenous catheter use in UK small animal practice.

The Journal of small animal practice·2024
Same author

Correction to: Primary care usage at the end of life: a retrospective cohort study of cancer patients using linked primary and hospital care data.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2024
Same author

Management of isolated anomalous systemic arterial supply to normal lung (ISSNL) during pregnancy.

QJM : monthly journal of the Association of Physicians·2024
Same author

Primary care usage at the end of life: a retrospective cohort study of cancer patients using linked primary and hospital care data.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2024
Same journal

Comparative profiles of pediatric Mendeliome: A Single-Centre 572-Whole-Exome Sequencing Study in Xinjiang.

Human heredity·2026
Same journal

Erratum.

Human heredity·2026
Same journal

Exploratory Analysis of HMGB1 Genetic Variants and Their Potential Association with Lung Cancer Susceptibility and Chemotherapy Response in a Chinese Population.

Human heredity·2025
Same journal

Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

Human heredity·2025
Same journal

Generalized Stable Population and Agent-Based Models of Phenotypic Transmission in Human Populations, with an Application to Body Size.

Human heredity·2025
Same journal

Proteinase-activated receptor 2 (PAR-2) expression and F2RL1 genetic variants are associated with asthma: a case-control study in the Chinese population.

Human heredity·2025
See all related articles

Accurate integrated metric maps are crucial for understanding complex traits and biological processes, despite the Human Genome Project

Area of Science:

  • Genomics
  • Human Genetics
  • Bioinformatics

Background:

  • The Human Genome Project's current focus on sequencing has created a misconception that gene mapping is complete.
  • Complex traits and biological processes like recombination require advanced mapping techniques.

Purpose of the Study:

  • To emphasize the ongoing and increasing need for accurate integrated metric maps.
  • To highlight the role of sequencing in refining genomic maps.
  • To define the future target of integrating location and functional information.

Main Methods:

  • Leveraging sequencing data to improve map resolution and accuracy.
  • Integrating physical mapping data with functional genomics information.
  • Utilizing homology, expression, and functional studies for data integration.

Related Experiment Videos

Main Results:

  • Sequencing efforts enhance the precision of genomic maps by providing accurate physical coordinates for markers and expressed sequences.
  • Annotated sequences serve as a key output, bridging sequencing and mapping.

Conclusions:

  • Accurate integrated metric maps remain essential for advancing genetic research, particularly for complex traits.
  • The future of genomics lies in the comprehensive integration of physical location and functional data.