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Quantifying Agonist Activity at G Protein-coupled Receptors
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Quantifying Agonist Activity at G Protein-coupled Receptors

Published on: December 26, 2011

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The physiological response to cardiovascular 'orphan' G protein-coupled receptor agonists

J M Hare, D A Kass, J S Stamler

    Nature Medicine
    |November 5, 1999
    PubMed

    Insights

    Cardiac pressor agents can decrease blood output per heartbeat. Cardiovascular hemodynamic principles help determine if this response is beneficial or harmful.

    Area of Science:

    • Cardiovascular physiology
    • Pharmacology

    Background:

    • Cardiac pressor agents are commonly used medications.
    • These agents often lead to a reduction in stroke volume, which is the amount of blood pumped with each heartbeat.

    Discussion:

    • The physiologic or maladaptive nature of this reduced stroke volume is crucial for patient outcomes.
    • Understanding the underlying cardiovascular hemodynamic principles is key to evaluating this response.

    Key Insights:

    • Reduced stroke volume from cardiac pressor agents requires careful assessment.
    • Hemodynamic principles provide a framework for distinguishing beneficial from detrimental effects.

    Outlook:

    • Further research into individualized hemodynamic assessments is warranted.
    • Optimizing the use of cardiac pressor agents depends on understanding their impact on cardiac output.

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