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Synthesis and antimycobacterial activity of some heteroarylcarboxamidrazone derivatives
D C Billington1, M D Coleman, J Ibiabuo
1Pharmaceutical Sciences Institute, Aston University, Aston Triangle, Birmingham, UK.
Drug Design and Discovery
|November 5, 1999
Abstract:
A series of pyridine-2-, pyrazine-2- and quinoline-2-carboxamidrazone derivatives was prepared in an automated fashion and tested against Mycobacterium fortuitum in a rapid screen. Seven pyridine-2-carboxamidrazone derivatives were investigated further and four were found to have inhibitory activity with compound 4af being the most active. The structure activity implications are discussed.