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Leukocyte function in children with malignancies.

L K Pickering, D C Anderson, S Choi

    Cancer
    |May 1, 1975
    PubMed
    Summary
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    Children with acute lymphocytic leukemia (ALL) show impaired leukocyte function, with higher resting hexose monophosphate shunt (HMPS) activity and reduced nitroblue tetrazolium (NBT) dye reduction compared to healthy children.

    Area of Science:

    • Immunology
    • Pediatric Oncology

    Background:

    • Leukocyte function is crucial for immune response.
    • Children with acute lymphocytic leukemia (ALL) and solid tumors may have altered immune cell function.
    • Assessing leukocyte function can provide insights into disease status and treatment effects.

    Purpose of the Study:

    • To evaluate leukocyte function in children with acute lymphocytic leukemia (ALL) and solid tumors.
    • To compare hexose monophosphate shunt (HMPS) activity and nitroblue tetrazolium (NBT) dye reduction in patients versus healthy controls.
    • To investigate the impact of infection and chemotherapy on leukocyte function in these patients.

    Main Methods:

    • Blood samples collected from 106 children with ALL or solid tumors (414 occasions) and 178 healthy children.

    Related Experiment Videos

  • Assessed resting and stimulated hexose monophosphate shunt (HMPS) activity.
  • Measured unstimulated and stimulated nitroblue tetrazolium (NBT) dye reduction.

    • Main Results:

    • Patients with malignant diseases exhibited significantly higher resting HMPS activity (p<0.01) and significantly lower stimulated HMPS activity (p<0.01) compared to controls.
    • Leukocytes from patients showed significantly reduced unstimulated NBT dye reduction (p<0.01) versus controls.
    • No significant differences in HMPS or NBT were observed related to bacterial infection, chemotherapy type, or ALL disease status (pre-treatment, remission, relapse).

    Conclusions:

    • Children with ALL and solid tumors display a functional impairment in leukocyte activity.
    • This impairment is evident even with normal peripheral blood and bone marrow cell morphology.
    • Leukocyte function assessment may serve as a biomarker in pediatric malignancies.