Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new analytical method of studying post-synaptic currents.

D S Poskitt1, K Doğançay, S H Chung

  • 1Department of Statistics, Australian National University, Canberra, ACT, Australia.

Mathematical Biosciences
|November 5, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-peak Light-emitting Diode Curing Units and Polymerization of 3D-printed Crown and Bridge Resin.

Operative dentistry·2023
Same author

Steroid-Refractory Autoimmune Myocarditis after Pembrolizumab Therapy: Failure of Equine Anti-Thymocyte Globulin to Prevent Heart Failure.

Journal of clinical case reports·2023
Same author

Observation of a 1/3 magnetization plateau in Pb<sub>2</sub>Cu<sub>10</sub>O<sub>4</sub>(SeO<sub>3</sub>)<sub>4</sub>Cl<sub>7</sub> arising from (Cu<sup>2+</sup>)<sub>7</sub> clusters of corner-sharing (Cu<sup>2+</sup>)<sub>4</sub> tetrahedra.

Dalton transactions (Cambridge, England : 2003)·2022
Same author

Effect of Deep Margin Elevation on Interfacial Gap Development of CAD/CAM Inlays after Thermomechanical Cycling.

Operative dentistry·2021
Same author

A novel model to manage air cargo disruptions caused by global catastrophes such as Covid-19.

Journal of air transport management·2021
Same author

Ytterbium-doped fibre femtosecond laser offers robust operation with deep and precise microsurgery of C. elegans neurons.

Scientific reports·2020

This study introduces a new method to analyze post-synaptic currents in neurons. It accurately estimates neurotransmitter release and synaptic current amplitude from noisy recordings.

Area of Science:

  • Neuroscience
  • Computational Biology
  • Signal Processing

Background:

  • Post-synaptic currents (PSCs) are crucial for neuronal communication.
  • Analyzing PSCs is challenging due to unknown neurotransmitter quantities and signal distortion.
  • Accurate analysis requires robust methods to handle noise and filter effects.

Purpose of the Study:

  • To develop a powerful methodology for analyzing PSCs recorded from central neurons.
  • To accurately estimate the amount of transmitter molecules released and the resulting synaptic current.
  • To investigate amplitude fluctuations in PSC data.

Main Methods:

  • Modeling synaptic current as a rapidly rising, slowly decaying function.
  • Using a time-invariant, linear filter to account for dendritic cable properties.

Related Experiment Videos

  • Employing quasi-profile likelihood estimation to determine signal parameters from noisy data.
  • Deconvolving recorded responses to estimate transmembrane current flux.
  • Utilizing non-parametric kernel smoothing for amplitude fluctuation analysis.

    • Main Results:

    • The methodology effectively estimates synaptic current amplitude and neurotransmitter release.
    • Optimal estimates of transmembrane current flux are obtained.
    • Amplitude fluctuations in PSC data are successfully investigated.
    • The method's effectiveness is demonstrated through simulation examples.

    Conclusions:

    • The presented methodology provides a robust framework for analyzing PSCs.
    • It enables accurate quantification of synaptic transmission parameters.
    • This approach enhances our understanding of neuronal signaling dynamics.