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Related Experiment Videos

Sentinel lymph node dissection in breast cancer.

A Bembenek1, T Reuhl, J Markwardt

  • 1Robert-Rössle-Klinik, Universitätsklinikum Charité, Berlin.

Swiss Surgery = Schweizer Chirurgie = Chirurgie Suisse = Chirurgia Svizzera
|November 5, 1999
PubMed
Summary
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Sentinel lymph node biopsy (snb) is a reliable method for staging early breast cancer patients with small tumors. This minimally invasive procedure accurately assesses nodal status, reducing the need for extensive surgery.

Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Sentinel lymph node biopsy (snb) is increasingly used for breast cancer staging.
  • Its efficacy and reliability are crucial for minimally invasive diagnostics.

Purpose of the Study:

  • To evaluate the experience, potential, and pitfalls of snb in breast cancer patients.
  • To assess the accuracy of snb based on tumor size.

Main Methods:

  • Conducted snb using a radionuclid method with preoperative lymphoscintigraphy and intraoperative gamma-probe detection.
  • Analyzed 146 breast cancer patients (stages I-III) from 11/95 to 3/99.
  • Correlated detection rates and accuracy with tumor diameter.

Main Results:

  • Detection rate and accuracy decreased with increasing tumor size (e.g., 94% detection for <1cm tumors, 63% for >5cm).

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  • For T1-2 tumors, snb accuracy was high (100% for <1cm, 97% for 1-3cm).
  • False-negative rates were low (4%), particularly in patients with lymphangiosis carcinomatosa.

    • Conclusions:

    • Radionuclid snb is reliable for nodal status evaluation in early breast cancer patients with tumors up to approximately 3 cm.
    • Snb is recommended for small tumors with clinically uninvolved axillary nodes or DCIS to rule out invasiveness.