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Related Experiment Videos

Herpes simplex virus encephalitis in pregnancy.

O Dupuis1, F Audibert, H Fernandez

  • 1Department of Obstetrics and Gynecology, Paris XI University, Hôpital Antoine Beclère, Clamart, France. osdupuis@club-internet.fr

Obstetrics and Gynecology
|November 5, 1999
PubMed
Summary
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Herpes simplex virus (HSV) encephalitis in pregnant women can cause severe neurologic issues. Early diagnosis with HSV PCR in cerebrospinal fluid (CSF) and prompt treatment with acyclovir and penicillin are crucial for maternal and fetal health.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Obstetrics

Background:

  • Herpes simplex virus (HSV) encephalitis poses a significant risk of neurologic impairment in pregnant women.
  • Diagnosing HSV encephalitis and assessing fetal contamination in pregnant patients presents challenges.

Observation:

  • Two cases of HSV encephalitis in pregnant women are presented, where the condition was initially unsuspected, leading to severe maternal neurologic deficits.
  • Polymerase chain reaction (PCR) testing of cerebrospinal fluid (CSF) confirmed HSV encephalitis in both cases.
  • In one case, fetal serum HSV PCR was utilized to rule out fetal contamination.

Findings:

  • HSV PCR of CSF is an effective diagnostic tool for identifying HSV encephalitis in pregnant women.
  • Fetal serum HSV PCR can reliably exclude fetal contamination.

Related Experiment Videos

  • Prompt treatment with acyclovir and penicillin is recommended upon suspicion of encephalitis in pregnancy.

    • Implications:

    • Early suspicion and diagnosis of HSV encephalitis in pregnancy are critical for timely intervention.
    • The combination of acyclovir and penicillin offers significant benefits that outweigh potential risks.
    • HSV PCR facilitates accurate diagnosis of fetal HSV infection, enabling appropriate management strategies.