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Updated: Aug 4, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Viral infections in interferon-gamma receptor deficiency
S E Dorman1, G Uzel, J Roesler
1Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Department of Pathology, National Institutes of Health, Bethesda, Maryland 20892, USA.
Abstract:
Interferon-gamma receptor deficiency is a recently described immunodeficiency that is associated with onset of severe mycobacterial infections in childhood. We describe the occurrence of symptomatic and often severe viral infections in 4 patients with interferon-gamma receptor deficiency and mycobacterial disease. The viral pathogens included herpes viruses, parainfluenza virus type 3, and respiratory syncytial virus. We conclude that patients with interferon-gamma receptor deficiency and mycobacterial disease have increased susceptibility to some viral pathogens.
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