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Constructing polyketides: from collie to combinatorial biosynthesis.

R Bentley1, J W Bennett

  • 1Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA. rbentley@pitt.edu

Annual Review of Microbiology
|November 5, 1999
PubMed
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Polyketide research is advancing with molecular biology, enabling new drug discovery. This review covers polyketide chemistry, biosynthesis, and combinatorial approaches for novel pharmaceuticals like antibiotics.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Polyketides are complex natural products with significant pharmaceutical applications.
  • Historical chemical methods laid the groundwork for current investigations.
  • The field has seen a shift towards genetic and molecular manipulation.

Purpose of the Study:

  • To review the evolution of polyketide research from chemical to molecular approaches.
  • To define polyketides in biosynthetic terms and explore combinatorial biosynthesis.
  • To highlight the potential for discovering new therapeutic agents.

Main Methods:

  • Review of historical chemical literature.
  • Analysis of current molecular biology and genetic manipulation techniques.

Related Experiment Videos

  • Examination of combinatorial biosynthesis strategies.

    • Main Results:

    • Successful production of hybrid polyketides through genetic engineering.
    • Identification of polyketides as sources for antibiotics, anthelminthics, and immunosuppressants.
    • Demonstration of the limitations of classical enzymological studies.

    Conclusions:

    • Molecular biology and genetics have ushered in a new era for polyketide research.
    • Combinatorial biosynthesis offers promising avenues for novel drug development.
    • Understanding polyketide biosynthesis is crucial for pharmaceutical innovation.